Pleurotus pulmonarius (FR.) Quél Crude Aqueous Extract Ameliorates Wistar-Kyoto Rat Thoracic Aortic Tissues and Vasodilation Responses

Pleurotus pulmonarius crude aqueous (CA) extract was previously reported to have therapeutic potential, thus its ability alleviate serum total cholesterol, vasodilation, and improve the aortic tissue structure in hypercholesterolemia rat model studied. Eight groups of Wistar-Kyoto rats were involved including normal (G1), (G2), treatment (G3 G5) prevention (G6 G8). Two doses CA; 0.5 g/kg body weight (BW), 2.0 BW, simvastatin 10 mg/kg BW orally fed Treatment induced with later treated CA/simvastatin, while given both hypercholesterolemia-diet CA/simvastatin simultaneously. The thoracic rings (TAR) subjected contractility study histopathology examination. In organ bath analysis, pre-contracted TAR G1 phenylephrine (PE) achieved 60% vasodilation response towards acetylcholine (ACh) whereas G2 unable respond ACh. G3 G5 failed dilate when ACh G6 G8 showed a slight improvement. repeated precontracted significantly dilated presence CA simvastatin. 100% at 3.0 mg/mL 2.4 73% 6.0 76.8% dilation recorded for 4.8 mg/mL. Histopathological examination found that able cells. These observations suggest helps condition hypercholesterolemic aorta.